Transfusion associated graft versus host disease

Transfusion Associated Graft versus Host Disease

Case 1: A five-year-old girl, a case of acute lymphoblastic leukemia (L1) presented with fever and lethargy a fortnight after receiving the late intensification chemotherapy consist-ing of vincristine, daunorubicin, cytarabine, etoposide, thioguanine and oral dexamethasone over a period of five days (UK ALL X protocol)(8). She had been in a sustained first remission for nearly 18 weeks. Examina...

Transfusion-associated graft-versus-host disease

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but almost uniformly lethal complication of blood transfusion. Although the graft-versus-host disease (GVHD) that occurs after allogeneic bone marrow transplantation and TA-GVHD share some clinical similarities, GVHD after bone marrow transplant is not uncommon and often responds positively to immunosuppression. The much rarer...

Transfusion-associated graft-versus-host disease.

Transfusion associated graft versus host disease (TA-GVHD) results from engraftment of viable donor T-lymphocytes in recipient that can not recognize or destroy them. It is seen in immunocompromised patients and pre-mature neonates. It can also occur in immunocompetent individuals receiving blood from first-degree relatives. It has emerged as single most common cause of death resulting from tra...

Transfusion-associated graft-versus-host disease

Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of transfusion of cellular blood components producing a graft-versus-host clinical picture with concomitant bone marrow aplasia. The disease is fulminant and rapidly fatal in the majority of patients. TA-GvHD is caused by transfused blood-derived, alloreactive T lymphocytes that attack host tissue, including bone ...

Prevention of transfusion-associated graft-versus-host disease.